Comfort Inn & Suites Santee SC is a cozy, comfortable and affordable place where you`ll be welcomed heartily. Stay with us at this well-regarded hotel in Santee SC and experience the best for less while taking in the abundant natural of beauty of Orangeburg County. Our hotel is close to Lake Marion, a jewel of central South Carolina. We`re also the first and best place to choose when seeking a place to stay near Lake Marion Golf Course and Lake Marion Bass Fishing as well as Santee Wildlife Refuge, Palmetto Trail and the Santee Welcome Center. Choose us over other hotels in Santee SC and you`ll get plenty of amenities. These include a satisfying free breakfast, free wifi, access to our fitness center and seasonal outdoor pool and more. We also have a business center for added convenience. Every guest room includes a fridge and microwave as well as premium bedding, a flat-screen television and a coffee maker. Some rooms have sofa beds too. Plus, staying with us allows you to earn rewards like free nights with Choice Privileges Rewards, an industry leading loyalty program. So what`s not to like? Reserve a room with us right away and see for yourself how great your stay in Santee can be.